TY - JOUR T1 - Particulate Matter Determination in LVPs Produced in Dutch Hospital Pharmacies, Part 1: Particle-Counting Accuracy JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 81 LP - 88 VL - 51 IS - 2 AU - J. Van Der Veen AU - Ph. Verbrugge AU - F. J. Van De Vaart AU - F. A. Boom Y1 - 1997/03/01 UR - http://journal.pda.org/content/51/2/81.abstract N2 - Reproducible particle counting using the light-obscuration technique is often troublesome because no absolute standard is available. Therefore, at the Laboratory of Dutch Pharmacists the “calibration-in-time” method was developed. This method enables checking of the amount of particles counted from a diluted latex suspension as a function of time. A particularity of the method is the one-step dilution procedure. The calibration-in-time method is compared with the particle-counting accuracy test according to the USP <788>. Advantages and disadvantages of both methods are discussed. ER -