RT Journal Article
SR Electronic
T1 Polymorphic Changes of Mannitol During Freeze-Drying: Effect of Surface-Active Agents
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 96
OP 101
VO 51
IS 2
A1 Haikala, Ritva
A1 Eerola, Riikka
A1 Tanninen, Veli Pekka
A1 Yliruusi, Jouko
YR 1997
UL http://journal.pda.org/content/51/2/96.abstract
AB The effect of polysorbate 80 on the crystalline properties of mannitol during freeze-drying was studied. Crystallinity and polymorphism play an important role in, e.g., the solubility and stability of freeze-dried products. Polysorbate 80 had an effect on both the polymorphism and the crystallinity of freeze-dried mannitol.