RT Journal Article SR Electronic T1 Solubilization of Diazepam JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 33 OP 36 VO 52 IS 1 A1 F. A. Alvarez Núñez A1 S. H. Yalkowsky YR 1998 UL http://journal.pda.org/content/52/1/33.abstract AB Several attempts to increase diazepam solubility are in the literature. This study discusses these different solubilization approaches. Specific reference is given to the rationale in the application of pH control, cosolvency, surfactants, and cyclodextrins. It was found than cosolvency is a more attractive means of solubilizing diazepam than either pH control, surfactants, or cyclodextrins. Advantages, assumptions, and limitations of these diazepam solubilization techniques are also described.