PT  - JOURNAL ARTICLE
AU  - Li, Ping
AU  - Patel, Hemali
AU  - Tabibi, S. Esmail
AU  - Vishnuvajjala, Rao
AU  - Yalkowsky, Samuel H.
TI  - Evaluation of Intravenous Flavopiridol Formulations
DP  - 1999 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 137--140
VI  - 53
IP  - 3
4099  - http://journal.pda.org/content/53/3/137.short
4100  - http://journal.pda.org/content/53/3/137.full
SO  - PDA J Pharm Sci Technol1999 May 01; 53
AB  - Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed.