TY - JOUR T1 - Evaluation of Intravenous Flavopiridol Formulations JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 137 LP - 140 VL - 53 IS - 3 AU - Ping Li AU - Hemali Patel AU - S. Esmail Tabibi AU - Rao Vishnuvajjala AU - Samuel H. Yalkowsky Y1 - 1999/05/01 UR - http://journal.pda.org/content/53/3/137.abstract N2 - Flavopiridol is currently under consideration as a parenteral treatment of breast tumors. The solubility of this poorly water-soluble compound can be increased by a number of methods. However, because of its low water solubility, precipitation of the solubilized drug upon injection can be a problem. The potential of several flavopiridol formulations to precipitate is evaluated using a static serial dilution technique. It is shown that formulations containing up to 10 mg/mL of flavopiridol which produce negligible precipitation on dilution can be developed. ER -