RT Journal Article
SR Electronic
T1 Determination of Amylose/Particulate Relationship in Hydroxyethylstarch
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 181
OP 185
VO 53
IS 4
A1 Stephens, Dennis
A1 Bares, Dale
A1 Robinson, Dan
A1 Pec, Edward
YR 1999
UL http://journal.pda.org/content/53/4/181.abstract
AB Visual particulate was observed to form in parenteral hydroxyethylstarch over 24 months during stability studies. The particulate was identified as being amylose using FT-IR microscopy. Amylose values were measured in the bulk drug using the starch-iodine reaction. The amylose numbers measured in the bulk drug were found to correlate well with the measured particulate values in the parenteral formulation.