RT Journal Article
SR Electronic
T1 Disinfection with Flash Lamps
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 264
OP 276
VO 54
IS 3
A1 Wekhof, Alexander
YR 2000
UL http://journal.pda.org/content/54/3/264.abstract
AB The analysis of published and new data on a pulsed disinfection is presented. It allows the conclusion that the pulsed disinfection mechanism includes both germicidal action of UVC light and a rupture of bacteria due to thermal stress, caused primarily by all UV components of the light pulse. The role of simultaneous cooling and heating of bacteria during a flash lamp pulse has been estimated and a direct detection of such a mechanism is proposed. It is suggested that an optimum pulsed light source for disinfection must have as much percentile content of a broad UV spectrum and a high peak power as is technically justified. Two new applications for pharmaceutics and medicine are suggested.