PT  - JOURNAL ARTICLE
AU  - Boom, F. A.
AU  - Van der Veen, J.
AU  - Verbrugge, Ph.
AU  - Van de Vaart, F. J.
AU  - Paalman, A. C. A.
AU  - Vos, Th.
TI  - Particulate Matter Determination in LVPs Produced in Dutch Hospital Pharmacies
DP  - 2000 Jul 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 343--358
VI  - 54
IP  - 4
4099  - http://journal.pda.org/content/54/4/343.short
4100  - http://journal.pda.org/content/54/4/343.full
SO  - PDA J Pharm Sci Technol2000 Jul 01; 54
AB  - The Laboratory of Dutch Pharmacists determines LVP particulate matter contamination of LVPs produced in Dutch hospital pharmacies. The investigated LVPs must conform to the NVZA/LNA criteria, which prescribes eight samples and sets limits for particles ≥ 2 μm, ≥ 5 μm, ≥ 10 μm, and ≥ 25 μm for both mean and mean + 2x standard deviation. LVPs produced in 500 mL glass containers or plastic containers mostly met the NVZA/LNA criteria, but LVPs produced in 100 mL glass containers showed higher levels of particulate matter contamination. The composition of the LVP significantly affected the extent of particulate matter contamination, but the effect was relatively small when compared to the influence of the type of container. LVPs produced in Dutch hospital pharmacies and LVPs obtained from pharmaceutical industries showed comparable amounts of particulate matter contamination.