PT  - JOURNAL ARTICLE
AU  - Colin S. Sinclair
AU  - Alan Tallentire
TI  - Definition of a Correlation Between Microbiological and Physical Particulate Barrier Performances for Porous Medical Packaging Materials
DP  - 2002 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 11--19
VI  - 56
IP  - 1
4099  - http://journal.pda.org/content/56/1/11.short
4100  - http://journal.pda.org/content/56/1/11.full
SO  - PDA J Pharm Sci Technol2002 Jan 01; 56
AB  - An experimental set up, assembled principally from components of commercially available filter test equipment, has allowed assessment of physical particulate barrier performance of porous materials. Employing twelve specially made papers with graded and widely different barrier properties, a physical particulate/microbiological correlation has been derived covering the 50,000 fold range of microbiological barrier performances seen in commercial porous medical packaging materials. The derived correlation has been shown to be independent of sheet structure and is applicable to the diverse structures that comprise commercial materials. A simple measurement of particle penetration is proposed as a means of assessing microbial barrier properties of such materials.