PT - JOURNAL ARTICLE AU - Walther, Marten AU - Rupertus, Volker AU - Seemann, Christina AU - Brecht, Jutta AU - Hormes, Robert AU - Swift, Robert W. TI - Pharmaceutical Vials with Extremely High Chemical Inertness DP - 2002 May 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 124--129 VI - 56 IP - 3 4099 - http://journal.pda.org/content/56/3/124.short 4100 - http://journal.pda.org/content/56/3/124.full SO - PDA J Pharm Sci Technol2002 May 01; 56 AB - Traditional type I glass containers are becoming more unsuitable for packaging modern diagnostics and drugs. When using certain drugs (high-pH formulations, complexing agents, drugs with low dosage, sensitivity to pH-shift or ion release), product degradation can occur, reducing the drug's performance, potency, and shelf-life. To prevent chemical interaction between the container and the content, a coating technology applying a silicon dioxide layer to the internal container surface can bring the solution.