PT  - JOURNAL ARTICLE
AU  - Marten Walther
AU  - Volker Rupertus
AU  - Christina Seemann
AU  - Jutta Brecht
AU  - Robert Hormes
AU  - Robert W. Swift
TI  - Pharmaceutical Vials with Extremely High Chemical Inertness
DP  - 2002 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 124--129
VI  - 56
IP  - 3
4099  - http://journal.pda.org/content/56/3/124.short
4100  - http://journal.pda.org/content/56/3/124.full
SO  - PDA J Pharm Sci Technol2002 May 01; 56
AB  - Traditional type I glass containers are becoming more unsuitable for packaging modern diagnostics and drugs. When using certain drugs (high-pH formulations, complexing agents, drugs with low dosage, sensitivity to pH-shift or ion release), product degradation can occur, reducing the drug's performance, potency, and shelf-life. To prevent chemical interaction between the container and the content, a coating technology applying a silicon dioxide layer to the internal container surface can bring the solution.