RT Journal Article
SR Electronic
T1 Pharmaceutical Vials with Extremely High Chemical Inertness
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 124
OP 129
VO 56
IS 3
A1 Walther, Marten
A1 Rupertus, Volker
A1 Seemann, Christina
A1 Brecht, Jutta
A1 Hormes, Robert
A1 Swift, Robert W.
YR 2002
UL http://journal.pda.org/content/56/3/124.abstract
AB Traditional type I glass containers are becoming more unsuitable for packaging modern diagnostics and drugs. When using certain drugs (high-pH formulations, complexing agents, drugs with low dosage, sensitivity to pH-shift or ion release), product degradation can occur, reducing the drug's performance, potency, and shelf-life. To prevent chemical interaction between the container and the content, a coating technology applying a silicon dioxide layer to the internal container surface can bring the solution.