PT  - JOURNAL ARTICLE
AU  - Preet MS Bedi
AU  - Mohinder P. Mahajan
AU  - Vijay K. Kapoor
TI  - Synthesis and Antibacterial Evaluation of 4-Substituted-2-Phenyl-1-<em>p</em>-Tolyl-4-Thiomethyl-1,3-Diazabuta-1,3-Dienes: A Novel Class of Antibacterial Agents
DP  - 2003 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 109--113
VI  - 57
IP  - 2
4099  - http://journal.pda.org/content/57/2/109.short
4100  - http://journal.pda.org/content/57/2/109.full
SO  - PDA J Pharm Sci Technol2003 Mar 01; 57
AB  - A series of novel-2-phenyl-l-p-tolyl-4-thiomethyl-1,3-diazabuta-l,3-dienes compounds (5a-5e) possessing morpholino, diethyl amino, pyrrolidino, piperidino and 2-aminopyridino groups respectively at C-4 were prepared by reaction of α-aryliminobenzyl isothiocyanates with secondary amines and S-alklyation of the resultant thioureas with aqueous potassium hydroxide. The isothiocyanates were obtained from easily available starting materials. These 1,3-diazabuta-1,3-dienes were obtained in pure form after recrystallization and their structures were established by analytical and spectral data. The synthesized compounds were screened for their antibacterial activity and some of them were found to exhibit signifi cant antibacterial activity.