RT Journal Article SR Electronic T1 Synthesis and Antibacterial Evaluation of 4-Substituted-2-Phenyl-1-p-Tolyl-4-Thiomethyl-1,3-Diazabuta-1,3-Dienes: A Novel Class of Antibacterial Agents JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 109 OP 113 VO 57 IS 2 A1 Preet MS Bedi A1 Mohinder P. Mahajan A1 Vijay K. Kapoor YR 2003 UL http://journal.pda.org/content/57/2/109.abstract AB A series of novel-2-phenyl-l-p-tolyl-4-thiomethyl-1,3-diazabuta-l,3-dienes compounds (5a-5e) possessing morpholino, diethyl amino, pyrrolidino, piperidino and 2-aminopyridino groups respectively at C-4 were prepared by reaction of α-aryliminobenzyl isothiocyanates with secondary amines and S-alklyation of the resultant thioureas with aqueous potassium hydroxide. The isothiocyanates were obtained from easily available starting materials. These 1,3-diazabuta-1,3-dienes were obtained in pure form after recrystallization and their structures were established by analytical and spectral data. The synthesized compounds were screened for their antibacterial activity and some of them were found to exhibit signifi cant antibacterial activity.