RT Journal Article SR Electronic T1 Phospholipid-Nucleic Acid Recognition: Developing an Immobilized Liposome Chromatography for DNA Separation and Analysis JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 232 OP 239 VO 60 IS 4 A1 Erhan Süleymanoǧlu YR 2006 UL http://journal.pda.org/content/60/4/232.abstract AB The basic physicochemical principles that determine nucleic acid-phospholipid recognition and selfassembly are presented, focusing on their use as promising stationary phases for separation and analyses of nucleic acids with various structures and properties. The utilization of immobilized liposome chromatography was designed as an aqueous, two-phase system for further studies of sequence- and topology-specific and non-specific nucleic acid binding features of phospholipids in the presence of cationic co-solutes. Such covalently attached liposomes are evaluated for their stability, binding affinities with nucleic acids and plasmids, as well as their subsequent compaction, in terms of their relevance to chromatographic applications.