TY - JOUR T1 - Profiling of Metal Ions Leached from Pharmaceutical Packaging Materials JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 337 LP - 342 VL - 60 IS - 6 AU - Kyle A. Fliszar AU - David Walker AU - Leonardo Allain Y1 - 2006/11/01 UR - http://journal.pda.org/content/60/6/337.abstract N2 - Metal leachables from packaging components can affect the safety and efficacy of a pharmaceutical formulation. As liquid formulations continue to contain surfactants, salts, and chelating agents coupled with lower drug levels, the interaction between the formulation and the packaging material becomes more important. This study examines the interaction of commonly used packaging materials with extraction solvents representative of liquid formulations found in the pharmaceutical industry stressed under conditions encountered during accelerated stability studies. ER -