PT  - JOURNAL ARTICLE
AU  - Fliszar, Kyle A.
AU  - Walker, David
AU  - Allain, Leonardo
TI  - Profiling of Metal Ions Leached from Pharmaceutical Packaging Materials
DP  - 2006 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 337--342
VI  - 60
IP  - 6
4099  - http://journal.pda.org/content/60/6/337.short
4100  - http://journal.pda.org/content/60/6/337.full
SO  - PDA J Pharm Sci Technol2006 Nov 01; 60
AB  - Metal leachables from packaging components can affect the safety and efficacy of a pharmaceutical formulation. As liquid formulations continue to contain surfactants, salts, and chelating agents coupled with lower drug levels, the interaction between the formulation and the packaging material becomes more important. This study examines the interaction of commonly used packaging materials with extraction solvents representative of liquid formulations found in the pharmaceutical industry stressed under conditions encountered during accelerated stability studies.