RT Journal Article
SR Electronic
T1 Profiling of Metal Ions Leached from Pharmaceutical Packaging Materials
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 337
OP 342
VO 60
IS 6
A1 Kyle A. Fliszar
A1 David Walker
A1 Leonardo Allain
YR 2006
UL http://journal.pda.org/content/60/6/337.abstract
AB Metal leachables from packaging components can affect the safety and efficacy of a pharmaceutical formulation. As liquid formulations continue to contain surfactants, salts, and chelating agents coupled with lower drug levels, the interaction between the formulation and the packaging material becomes more important. This study examines the interaction of commonly used packaging materials with extraction solvents representative of liquid formulations found in the pharmaceutical industry stressed under conditions encountered during accelerated stability studies.