PT  - JOURNAL ARTICLE
AU  - Dongkai Wang
AU  - Peng Zhao
AU  - Fude Cui
AU  - Xiang Li
TI  - Preparation and Characterization of Solid Lipid Nanoparticles Loaded with Total Flavones of <em>Hippophae rhamnoides</em> (TFH)
DP  - 2007 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 110--120
VI  - 61
IP  - 2
4099  - http://journal.pda.org/content/61/2/110.short
4100  - http://journal.pda.org/content/61/2/110.full
SO  - PDA J Pharm Sci Technol2007 Mar 01; 61
AB  - Solid lipid nanoparticles (SLNs) containing total flavones of Hippophae rhamnoides (TFH) were prepared by high-pressure homogenization (HPH), by both hot HPH and cold HPH. The influence of process parameters (lipid matrix, lipid concentration, carbohydrate type and its concentration) on the SLN size distribution, zeta potential, entrapment efficiency, crystal form, and in vitro release profile was investigated. The highest entrapment efficiency for TFH, at around 93%, was found for SLNs composed of TFH/Compritol 888 ATO in a 1:30 molar ratio and made by cold HPH. The advantages of TFH SLNs are the improved oral bioavailability of TFH and the prolonged mean retention time and drug release time.