RT Journal Article
SR Electronic
T1 Preparation and Characterization of Solid Lipid Nanoparticles Loaded with Total Flavones of <em>Hippophae rhamnoides</em> (TFH)
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 110
OP 120
VO 61
IS 2
A1 Wang, Dongkai
A1 Zhao, Peng
A1 Cui, Fude
A1 Li, Xiang
YR 2007
UL http://journal.pda.org/content/61/2/110.abstract
AB Solid lipid nanoparticles (SLNs) containing total flavones of Hippophae rhamnoides (TFH) were prepared by high-pressure homogenization (HPH), by both hot HPH and cold HPH. The influence of process parameters (lipid matrix, lipid concentration, carbohydrate type and its concentration) on the SLN size distribution, zeta potential, entrapment efficiency, crystal form, and in vitro release profile was investigated. The highest entrapment efficiency for TFH, at around 93%, was found for SLNs composed of TFH/Compritol 888 ATO in a 1:30 molar ratio and made by cold HPH. The advantages of TFH SLNs are the improved oral bioavailability of TFH and the prolonged mean retention time and drug release time.