TY - JOUR T1 - Solid Dispersion Adsorbates for Enhancement of Dissolution Rates of Drugs JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 97 LP - 101 VL - 61 IS - 2 AU - Deepti AU - Harish Dureja AU - A.K. Madan Y1 - 2007/03/01 UR - http://journal.pda.org/content/61/2/97.abstract N2 - Amalgamation of solid dispersion and melt adsorption technologies was utilized for enhancing the dissolution rate of poorly soluble drugs. Glibenclamide was employed as a model drug. PEG6000 and Gelucire44/14 were used as hydrophilic carriers for the preparation of solid dispersions, and lactose was utilized as an adsorbent for the preparation of solid dispersion adsorbates. A high dissolution rate of solid dispersion adsorbates was observed when compared to solid dispersions alone and one of the marketed products. ER -