PT - JOURNAL ARTICLE AU - Deepti AU - Harish Dureja AU - A.K. Madan TI - Solid Dispersion Adsorbates for Enhancement of Dissolution Rates of Drugs DP - 2007 Mar 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 97--101 VI - 61 IP - 2 4099 - http://journal.pda.org/content/61/2/97.short 4100 - http://journal.pda.org/content/61/2/97.full SO - PDA J Pharm Sci Technol2007 Mar 01; 61 AB - Amalgamation of solid dispersion and melt adsorption technologies was utilized for enhancing the dissolution rate of poorly soluble drugs. Glibenclamide was employed as a model drug. PEG6000 and Gelucire44/14 were used as hydrophilic carriers for the preparation of solid dispersions, and lactose was utilized as an adsorbent for the preparation of solid dispersion adsorbates. A high dissolution rate of solid dispersion adsorbates was observed when compared to solid dispersions alone and one of the marketed products.