PT  - JOURNAL ARTICLE
AU  - P. Gowrishankar
AU  - S. Baboota
TI  - Preparation and Properties of Valdecoxib-Hydroxypropyl βeta-cyclodextrin Inclusion Complex
DP  - 2007 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 175--182
VI  - 61
IP  - 3
4099  - http://journal.pda.org/content/61/3/175.short
4100  - http://journal.pda.org/content/61/3/175.full
SO  - PDA J Pharm Sci Technol2007 May 01; 61
AB  - Valdecoxib is a non-steroidal anti-inflammatory drug used in the treatment of rheumatoid and osteoarthritis. It is practically insoluble in water. Incidence of adverse events such as nausea has been reported in some trials. Therefore, an attempt was made to improve the aqueous solubility of the drug by making an inclusion complex using hydroxypropyl βeta-cyclodextrin (HPβ-CD). The complexes were prepared by physical mixture and freeze-drying methods. The different methods employed for evaluation—including differential scanning calorimetry, Fourier transform infrared spectral analysis, and scanning electron microscopy studies—indicated complete formation of the complex by the freeze-drying method in a molar ratio of 1:1. The prepared complexes showed an improved in vitro dissolution profile and better anti-inflammatory activity as compared to the pure drug.