PT - JOURNAL ARTICLE AU - Peng-Fei Yue AU - Hai-Long Yuan AU - Ming Yang AU - Rong-Hui You AU - Long-Bo Cong AU - Jun Zhu AU - Qi Wang AU - Wei-Feng Zhu AU - Xiao-He Xiao TI - Preparation, Characterization, and Pharmacokinetic Evaluation of Puerarin Submicron Emulsion DP - 2008 Jan 01 TA - PDA Journal of Pharmaceutical Science and Technology PG - 32--45 VI - 62 IP - 1 4099 - http://journal.pda.org/content/62/1/32.short 4100 - http://journal.pda.org/content/62/1/32.full SO - PDA J Pharm Sci Technol2008 Jan 01; 62 AB - A novel formulation of puerarin was studied. Puerarin submicron emulsion was prepared by complex phase inversion–high-pressure homogenization technology. Characterization, distribution of drug in emulsion, short-term stability, and pharmacokinetics of emulsion were evaluated. The mean diameter and zeta potential of puerarin emulsion were 188.14 nm and −29.45 mv, respectively. The distribution range of puerarin emulsion was very narrow. The concentration of puerarin in the interfacial surface, oil droplet, water, and liposome-micelles were 7.821, 1.079, 0.637 and 0.423 mg/mL, respectively. Puerarin submicron emulsion was stable for a period of 3 months. The area under the whole blood concentration-time curve of rabbits after intravenous administration of puerarin emulsion was 1.718-fold higher than that of rabbits of intravenous administration of puerarin (P < 0.05). And compared with the puerarin group, the elimination rate of puerarin emulsion group was significantly decreased (P < 0.05), and the biological half-life and the mean retention time of puerarin emulsion were markedly increased (P < 0.05).