RT Journal Article
SR Electronic
T1 Preparation, Characterization, and Pharmacokinetic Evaluation of Puerarin Submicron Emulsion
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 32
OP 45
VO 62
IS 1
A1 Yue, Peng-Fei
A1 Yuan, Hai-Long
A1 Yang, Ming
A1 You, Rong-Hui
A1 Cong, Long-Bo
A1 Zhu, Jun
A1 Wang, Qi
A1 Zhu, Wei-Feng
A1 Xiao, Xiao-He
YR 2008
UL http://journal.pda.org/content/62/1/32.abstract
AB A novel formulation of puerarin was studied. Puerarin submicron emulsion was prepared by complex phase inversion–high-pressure homogenization technology. Characterization, distribution of drug in emulsion, short-term stability, and pharmacokinetics of emulsion were evaluated. The mean diameter and zeta potential of puerarin emulsion were 188.14 nm and −29.45 mv, respectively. The distribution range of puerarin emulsion was very narrow. The concentration of puerarin in the interfacial surface, oil droplet, water, and liposome-micelles were 7.821, 1.079, 0.637 and 0.423 mg/mL, respectively. Puerarin submicron emulsion was stable for a period of 3 months. The area under the whole blood concentration-time curve of rabbits after intravenous administration of puerarin emulsion was 1.718-fold higher than that of rabbits of intravenous administration of puerarin (P < 0.05). And compared with the puerarin group, the elimination rate of puerarin emulsion group was significantly decreased (P < 0.05), and the biological half-life and the mean retention time of puerarin emulsion were markedly increased (P < 0.05).