PT  - JOURNAL ARTICLE
AU  - Andress, Mark
AU  - Dull, Henry
AU  - Gurley, Thomas
AU  - Remo, Ed
AU  - Grillo, John
AU  - Navasca, Fredy
AU  - Berger, Thomas
TI  - Oxygen Permeation and Microbial Ingress through a Film-Coated and Uncoated Elastomeric Closure in A Glass Vial: A Comparative Study
DP  - 2004 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 32--44
VI  - 58
IP  - 1
4099  - http://journal.pda.org/content/58/1/32.short
4100  - http://journal.pda.org/content/58/1/32.full
SO  - PDA J Pharm Sci Technol2004 Jan 01; 58
AB  - This is a comparative study of oxygen permeation and microbial ingress into a drug vial stopper that is an elastomeric pharmaceutical compound versus the same compound coated with a thin Teflon-type film coating. The objective of this study is to determine if the film coating causes any changes in the rate of oxygen permeation or microbial ingress into the vial from the environment. From the data obtained it is concluded that the film did not change either the oxygen or microbial ingress into the vial; therefore the stoppers are essentially equivalent with respect to these parameters.