PT  - JOURNAL ARTICLE
AU  - Gupta, Piyush
AU  - Bansal, Arvind K.
TI  - Modeling of Drug Release from Celecoxib–PVP–Meglumine Amorphous Systems
DP  - 2005 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 346--354
VI  - 59
IP  - 6
4099  - http://journal.pda.org/content/59/6/346.short
4100  - http://journal.pda.org/content/59/6/346.full
SO  - PDA J Pharm Sci Technol2005 Nov 01; 59
AB  - An empirical assessment of drug release from amorphous systems of celecoxib (CEL), poly(vinyl pyrrolidone) (PVP), and meglumine (MEG) was performed and compared with that for its crystalline form. CEL–PVP (4:1 w/w) binary and CEL–PVP–MEG (7:2:1 w/w) ternary amorphous systems provided higher drug dissolution. Mathematical modeling of drug release data was found to best fit the Hixson-Crowell release model. The biphasic drug release during a 6-h duration exhibited higher release kinetics in the first phase due to the presence of drug in amorphous form. The release kinetics subdued in the latter phase due to ongoing devitrification process in amorphous systems. A comprehensive understanding of drug release from amorphous systems will accentuate the rationalized design of amorphous drug delivery systems.