PT  - JOURNAL ARTICLE
AU  - S. Narasimha Murthy
AU  - B.A. Vishwanath
AU  - S. Bharath
TI  - Bioadhesive Tablets for Controlled Transdermal Delivery of Drugs
DP  - 2005 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 355--359
VI  - 59
IP  - 6
4099  - http://journal.pda.org/content/59/6/355.short
4100  - http://journal.pda.org/content/59/6/355.full
SO  - PDA J Pharm Sci Technol2005 Nov 01; 59
AB  - Transdermal bioadhesive tablets were formulated by the direct compression method and evaluated. Carboxyfluorescein (CF) was used as a model permeant. The compression parameters were kept consistent and the composition of the formulation was varied to alter the release rate of the drug from the formulations. The dosage form was evaluated for physicochemical, adherence, and in vitro diffusion parameters. The transdermal flux of the drug decreased with the increasing ratio of Ethyl cellulose (EC)/hydroxypropyl cellulose (HPC). The test formulations were subjected to pharmacokinetic studies in mice. The formulations were able to maintain a steady state plasma concentration up to 12 hours. They were found to be safe for transdermal use as interpreted from skin irritation studies carried out on rabbits.