TY - JOUR T1 - Passage-Delaying Microbeads for Controlled Delivery of Loratadine JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 421 LP - 428 VL - 62 IS - 6 AU - Shashi Kiran Mishra AU - Anil K. Philip AU - Kamla Pathak Y1 - 2008/11/01 UR - http://journal.pda.org/content/62/6/421.abstract N2 - A passage-delaying, multiple unit, controlled release system of loratadine was designed to increase residence time in the stomach involving minimum contact with the gastric mucosa. Oil-entrapped floating microbeads prepared using the emulsion gelation method were optimized by a 23 factorial design and a polymer ratio of 1.5:0.5 (casein:sodium alginate) by weight, and 15% w/v of oil (mineral oil/castor oil) and 1 M calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in acid phthalate buffer, pH 3.12, demonstrated a sustained release for 8 h that best fitted the peppas model with n < 0.45. The ethylcellulose coating of the passage-delaying microbeads optimized by a 22 factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h. ER -