RT Journal Article
SR Electronic
T1 Passage-Delaying Microbeads for Controlled Delivery of Loratadine
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 421
OP 428
VO 62
IS 6
A1 Shashi Kiran Mishra
A1 Anil K. Philip
A1 Kamla Pathak
YR 2008
UL http://journal.pda.org/content/62/6/421.abstract
AB A passage-delaying, multiple unit, controlled release system of loratadine was designed to increase residence time in the stomach involving minimum contact with the gastric mucosa. Oil-entrapped floating microbeads prepared using the emulsion gelation method were optimized by a 23 factorial design and a polymer ratio of 1.5:0.5 (casein:sodium alginate) by weight, and 15% w/v of oil (mineral oil/castor oil) and 1 M calcium chloride solution were selected as the optimized processing conditions for the desired buoyancy and physical stability. In vitro drug release in acid phthalate buffer, pH 3.12, demonstrated a sustained release for 8 h that best fitted the peppas model with n < 0.45. The ethylcellulose coating of the passage-delaying microbeads optimized by a 22 factorial design resulted in a controlled release formulation of loratadine that provided zero-order release for 8 h.