PT  - JOURNAL ARTICLE
AU  - Vishal Gupta
AU  - Meenal Gupta
AU  - Anil Kumar Madan
TI  - Development of Modified Dosage Form for Enhancement of Dissolution Rate through Amalgamation of Solid Dispersion and Cube Sugar or Sintering Technology Using Famotidine as a Model Drug
DP  - 2009 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 58--70
VI  - 63
IP  - 1
4099  - http://journal.pda.org/content/63/1/58.short
4100  - http://journal.pda.org/content/63/1/58.full
SO  - PDA J Pharm Sci Technol2009 Jan 01; 63
AB  - An amalgamation of solid dispersion and cube sugar or sintering technologies was utilized for preparing a high dissolution rate, fast-release dosage form for poorly water soluble drug(s). Famotidine was employed as a model drug. Solid dispersion particles of famotidine were prepared using the fusion method employing xylitol as an hydrophilic carrier, and the particles' solid state performance was characterized by means of differential scanning calorimetry, Fourier transformed infrared spectroscopy, and X-ray powder diffractometry. Solid dispersion particles of famotidine were encompassed directly into tablets in a manner similar to that adopted for cube sugar production and sintering technology. The effect of different particle sizes of solid dispersion was also studied in relation to tablet disintegration. The resulting tablets were only rapidly disintegrating owing to capillarity but also ensure the rapid dissolution of poorly water-soluble drug when compared to other marketed products.