PT  - JOURNAL ARTICLE
AU  - Nazar M. Ranjha
TI  - Polymeric Micelles of Ammonium Palmitoyl Glycol Chitosan and Solubilization of Camptothecin
DP  - 2009 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 81--87
VI  - 63
IP  - 1
4099  - http://journal.pda.org/content/63/1/81.short
4100  - http://journal.pda.org/content/63/1/81.full
SO  - PDA J Pharm Sci Technol2009 Jan 01; 63
AB  - Chitosan is a polysaccharide possessing biodegradable and biocompatible properties. Chitosan and its derivatives are used as excipients in drug delivery, as mucoadhesive polymers, and as a permeation enhancer for drug delivery in vitro at mucosal epithelia; and micelles of chitosan derivatives are used for solubilization of hydrophobic drug. Twenty-five samples of ammonium palmitoyl glycol chitosan were synthesized after reacting glycol chitosan with palmitic acid N-hydroxysuccinimide and methyl iodide with different concentration of hydrophobic and hydrophilic component. The objective was to identify suitable combinations of hydrophilicity and hydrophobicity which dissolve maximum water-insoluble camptothecin drug. In conclusion, the more hydrophilic and hydrophobic polymers are not suitable for soubilization of camptothcin.