RT Journal Article
SR Electronic
T1 Polymeric Micelles of Ammonium Palmitoyl Glycol Chitosan and Solubilization of Camptothecin
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 81
OP 87
VO 63
IS 1
A1 Ranjha, Nazar M.
YR 2009
UL http://journal.pda.org/content/63/1/81.abstract
AB Chitosan is a polysaccharide possessing biodegradable and biocompatible properties. Chitosan and its derivatives are used as excipients in drug delivery, as mucoadhesive polymers, and as a permeation enhancer for drug delivery in vitro at mucosal epithelia; and micelles of chitosan derivatives are used for solubilization of hydrophobic drug. Twenty-five samples of ammonium palmitoyl glycol chitosan were synthesized after reacting glycol chitosan with palmitic acid N-hydroxysuccinimide and methyl iodide with different concentration of hydrophobic and hydrophilic component. The objective was to identify suitable combinations of hydrophilicity and hydrophobicity which dissolve maximum water-insoluble camptothecin drug. In conclusion, the more hydrophilic and hydrophobic polymers are not suitable for soubilization of camptothcin.