RT Journal Article
SR Electronic
T1 Critical Influences of Particles, Pores, and Prefilters in Sterilizing Filtration
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 240
OP 244
VO 63
IS 3
A1 Russell E. Madsen
A1 Theodore H. Meltzer
YR 2009
UL http://journal.pda.org/content/63/3/240.abstract
AB Sterilizing filtration process variables can cause unpredictable results and post-filtration integrity test values that are not representative of those obtained during validation of the filtration process. This paper discusses several points to consider in sterilizing filtration designed to assure the validated process is robust and consistently yields a sterile filtrate. These points include pore- and particle-size distributions, the use and choice of prefilters, pore configuration, and the use of redundant (serial) filtration.