%0 Journal Article %A Daniel J. Zuccarello %A Michael P. Murphy %A Richard F. Meyer %A Paul A. Winslow %T A Comprehensive Approach for the Determination of Extractable and Leachable Metals in Pharmaceutical Products by Inductively-Coupled Plasma %D 2009 %J PDA Journal of Pharmaceutical Science and Technology %P 339-352 %V 63 %N 4 %X A comprehensive digestive approach for determining the extractable and leachable metals in pharmaceutical products by inductively-coupled plasma is investigated. This study examines several acid digestion strategies for packaging materials, containers, and formulated products for complete trace metals analysis. Packaging materials, a food product, and a simulated drug product are evaluated for leachable metals by stressing the materials under accelerated stability conditions. Trace metal profiles of 64 elements for these materials are reported. %U https://journal.pda.org/content/pdajpst/63/4/339.full.pdf