RT Journal Article SR Electronic T1 A Comprehensive Approach for the Determination of Extractable and Leachable Metals in Pharmaceutical Products by Inductively-Coupled Plasma JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 339 OP 352 VO 63 IS 4 A1 Daniel J. Zuccarello A1 Michael P. Murphy A1 Richard F. Meyer A1 Paul A. Winslow YR 2009 UL http://journal.pda.org/content/63/4/339.abstract AB A comprehensive digestive approach for determining the extractable and leachable metals in pharmaceutical products by inductively-coupled plasma is investigated. This study examines several acid digestion strategies for packaging materials, containers, and formulated products for complete trace metals analysis. Packaging materials, a food product, and a simulated drug product are evaluated for leachable metals by stressing the materials under accelerated stability conditions. Trace metal profiles of 64 elements for these materials are reported.