PT  - JOURNAL ARTICLE
AU  - Corrigan, Damion K.
AU  - Cauchi, Michael
AU  - Piletsky, Sergey
AU  - Mccrossen, Sean
TI  - Application of Surface-Enhanced Raman Spectroscopy (SERS) for Cleaning Verification in Pharmaceutical Manufacture
DP  - 2009 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 568--574
VI  - 63
IP  - 6
4099  - http://journal.pda.org/content/63/6/568.short
4100  - http://journal.pda.org/content/63/6/568.full
SO  - PDA J Pharm Sci Technol2009 Nov 01; 63
AB  - Cleaning verification is the process by which pharmaceutical manufacturing equipment is determined as sufficiently clean to allow manufacture to continue. Surface-enhanced Raman spectroscopy (SERS) is a very sensitive spectroscopic technique capable of detection at levels appropriate for cleaning verification. In this paper, commercially available Klarite™ SERS substrates were employed in order to obtain the necessary enhancement of signal for the identification of chemical species at concentrations of 1 to 10 ng/cm2, which are relevant to cleaning verification. The SERS approach was combined with principal component analysis in the identification of drug compounds recovered from a contaminated steel surface.© PDA, Inc. 2009