RT Journal Article
SR Electronic
T1 Application of Surface-Enhanced Raman Spectroscopy (SERS) for Cleaning Verification in Pharmaceutical Manufacture
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 568
OP 574
VO 63
IS 6
A1 Corrigan, Damion K.
A1 Cauchi, Michael
A1 Piletsky, Sergey
A1 Mccrossen, Sean
YR 2009
UL http://journal.pda.org/content/63/6/568.abstract
AB Cleaning verification is the process by which pharmaceutical manufacturing equipment is determined as sufficiently clean to allow manufacture to continue. Surface-enhanced Raman spectroscopy (SERS) is a very sensitive spectroscopic technique capable of detection at levels appropriate for cleaning verification. In this paper, commercially available Klarite™ SERS substrates were employed in order to obtain the necessary enhancement of signal for the identification of chemical species at concentrations of 1 to 10 ng/cm2, which are relevant to cleaning verification. The SERS approach was combined with principal component analysis in the identification of drug compounds recovered from a contaminated steel surface.© PDA, Inc. 2009