%0 Journal Article %A Dennis Jenke %A Tom Couch %A Amy Gillum %T Comparison of Solute-Binding Properties of Plastic Materials Used as Pharmaceutical Product Containers %D 2010 %J PDA Journal of Pharmaceutical Science and Technology %P 37-43 %V 64 %N 1 %X Material/water equilibrium binding constants (Eb) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute binding by the plasticized polyvinyl chloride material was greater, by nearly an order of magnitude, than the binding by the polyolefin (on an equal weight basis). The utilization of the binding constants to facilitate container compatibility assessments (e.g., drug loss by container binding) for drug-containing products is discussed.© PDA, Inc. 2010 %U https://journal.pda.org/content/pdajpst/64/1/37.full.pdf