PT  - JOURNAL ARTICLE
AU  - Dennis Jenke
AU  - Tom Couch
AU  - Amy Gillum
TI  - Comparison of Solute-Binding Properties of Plastic Materials Used as Pharmaceutical Product Containers
DP  - 2010 Jan 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 37--43
VI  - 64
IP  - 1
4099  - http://journal.pda.org/content/64/1/37.short
4100  - http://journal.pda.org/content/64/1/37.full
SO  - PDA J Pharm Sci Technol2010 Jan 01; 64
AB  - Material/water equilibrium binding constants (Eb) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute binding by the plasticized polyvinyl chloride material was greater, by nearly an order of magnitude, than the binding by the polyolefin (on an equal weight basis). The utilization of the binding constants to facilitate container compatibility assessments (e.g., drug loss by container binding) for drug-containing products is discussed.© PDA, Inc. 2010