RT Journal Article SR Electronic T1 Comparison of Solute-Binding Properties of Plastic Materials Used as Pharmaceutical Product Containers JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 37 OP 43 VO 64 IS 1 A1 Jenke, Dennis A1 Couch, Tom A1 Gillum, Amy YR 2010 UL http://journal.pda.org/content/64/1/37.abstract AB Material/water equilibrium binding constants (Eb) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute binding by the plasticized polyvinyl chloride material was greater, by nearly an order of magnitude, than the binding by the polyolefin (on an equal weight basis). The utilization of the binding constants to facilitate container compatibility assessments (e.g., drug loss by container binding) for drug-containing products is discussed.© PDA, Inc. 2010