TY - JOUR T1 - Comparison of Solute-Binding Properties of Plastic Materials Used as Pharmaceutical Product Containers JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 37 LP - 43 VL - 64 IS - 1 AU - Dennis Jenke AU - Tom Couch AU - Amy Gillum Y1 - 2010/01/01 UR - http://journal.pda.org/content/64/1/37.abstract N2 - Material/water equilibrium binding constants (Eb) were determined for 11 organic solutes and 2 plastic materials commonly used in pharmaceutical product containers (plasticized polyvinyl chloride and polyolefin). In general, solute binding by the plasticized polyvinyl chloride material was greater, by nearly an order of magnitude, than the binding by the polyolefin (on an equal weight basis). The utilization of the binding constants to facilitate container compatibility assessments (e.g., drug loss by container binding) for drug-containing products is discussed.© PDA, Inc. 2010 ER -