PT  - JOURNAL ARTICLE
AU  - Philippe Lam
AU  - Al Stern
TI  - Visualization Techniques for Assessing Design Factors That Affect the Interaction between Pharmaceutical Vials and Stoppers
DP  - 2010 Mar 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 182--187
VI  - 64
IP  - 2
4099  - http://journal.pda.org/content/64/2/182.short
4100  - http://journal.pda.org/content/64/2/182.full
SO  - PDA J Pharm Sci Technol2010 Mar 01; 64
AB  - We developed several techniques for visualizing the fit between a stopper and a vial in the critical flange area, a location typically hidden from view. Using these tools, it is possible to identify surfaces involved in forming the initial seal immediately after stopper insertion. We present examples illustrating important design elements that can contribute to forming a robust primary package. These techniques can also be used for component screening by facilitating the identification of combinations that do not fit well together so that they can be eliminated early in the selection process.© PDA, Inc. 2010