RT Journal Article
SR Electronic
T1 Screening of Counterfeit Cephalosporin and Discrimination from Penicillins by High-Throughput Chemical Color Tests
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 97
OP 100
VO 64
IS 2
A1 B. K. Singh
A1 D. V. Parwate
A1 S. K. Shukla
YR 2010
UL http://journal.pda.org/content/64/2/97.abstract
AB To combat the global upsurge in counterfeiting of antibiotics, rapid screening tests offering identification and binary (yes/no) information are required. Cephalosporins are susceptible to counterfeiting due to high prescription rates and prices. We propose a scheme consisting of a pair of chemical color tests for the screening of cephalosporins. The first test is based on the reducing behavior of cephalosporins towards iodate and iodine under strongly acidic conditions. The second test involves alkaline desulphurization and makes the scheme highly selective for cephalosporins. Penicillins and other antibiotics do not interfere with the proposed scheme. The tests have virtues of simplicity, ruggedness, and high-throughput.© PDA, Inc. 2010