PT  - JOURNAL ARTICLE
AU  - Mittapalli Pavan Kumar
AU  - G. Y. Srawan Kumar
AU  - Shashank Apte
AU  - Yamasani Madhusudan Rao
TI  - Review of Solubilization Techniques for a Poorly Water-Soluble Drug: Carbamazepine
DP  - 2010 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 264--277
VI  - 64
IP  - 3
4099  - http://journal.pda.org/content/64/3/264.short
4100  - http://journal.pda.org/content/64/3/264.full
SO  - PDA J Pharm Sci Technol2010 May 01; 64
AB  - Solubility behavior of drugs remains one of the most challenging aspects in formulation development. With the introduction of various solubility improvement techniques it should be possible to overcome solubility-linked issues. Several years of research and various novel techniques for improvement of drug solubility have resulted in only a few marketed products. There are various techniques that were studied in depth to improve carbamazepine (CBZ) solubility. Several in vitro and in vivo studies have shown significant improvement in dissolution and bioavailability of CBZ. This article begins with an overview of the historical background and definitions of the various techniques, including the novel ones. The second part of the article is devoted to the techniques, materials used, procedures, and characterization of various developed formulations. The current review is further extended specifically to drug dissolution in relation to drug crystalline in various solubilization approaches.© PDA, Inc. 2010