RT Journal Article
SR Electronic
T1 Animal Cell Substrates: Back to the Future
JF PDA Journal of Pharmaceutical Science and Technology
JO PDA J Pharm Sci Technol
FD Parenteral Drug Association (PDA)
SP 375
OP 378
VO 64
IS 5
A1 Petricciani, John
YR 2010
UL http://journal.pda.org/content/64/5/375.abstract
AB The acceptability of animal cell substrates for the manufacture of biological products, especially vaccines, has been an issue in one form or another since the development of cell cultures in the 1950s. Here the major cell substrate events of the past 50 years are briefly reviewed, and recent progress in resolving longstanding issues is highlighted.