TY - JOUR T1 - Experiences with HEK293: A Human Cell Line JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 392 LP - 395 VL - 64 IS - 5 AU - Michael J Rubino Y1 - 2010/09/01 UR - http://journal.pda.org/content/64/5/392.abstract N2 - The paper describes considerations taken with regard to a recombinant human cell line (HEK293) producing a therapeutic protein. When working with HEK293 cells, besides standard viral safety issues, special precautions should be taken because this cell line is susceptible to infection by numerous viruses. A viral contamination event occurred with this cell line even after a number of precautions were taken. ER -