PT  - JOURNAL ARTICLE
AU  - Lutgen, Mark
TI  - Chlorine Dioxide Remediation of a Virus-Contaminated Manufacturing Facility
AID  - 10.5731/pdajpst.2011.00830
DP  - 2011 Nov 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 620--624
VI  - 65
IP  - 6
4099  - http://journal.pda.org/content/65/6/620.short
4100  - http://journal.pda.org/content/65/6/620.full
SO  - PDA J Pharm Sci Technol2011 Nov 01; 65
AB  - CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1–3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Chlorine dioxide fumigation was successfully used to decontaminate a virally contaminated biotech manufacturing facility. Addressing safety, product quality, and corrosion risks were important factors in planning the building fumigation. Studies were performed to define the conditions in which minute mouse virus (MMV) is inactivated by chlorine dioxide and to understand equipment and facility risks. Written plans and procedures documented activities necessary to safely fumigate the building and requalify it to manufacture commercial product.