RT Journal Article SR Electronic T1 Chlorine Dioxide Remediation of a Virus-Contaminated Manufacturing Facility JF PDA Journal of Pharmaceutical Science and Technology JO PDA J Pharm Sci Technol FD Parenteral Drug Association (PDA) SP 620 OP 624 DO 10.5731/pdajpst.2011.00830 VO 65 IS 6 A1 Lutgen, Mark YR 2011 UL http://journal.pda.org/content/65/6/620.abstract AB CONFERENCE PROCEEDING Proceedings of the PDA/FDA Adventitious Viruses in Biologics: Detection and Mitigation Strategies Workshop in Bethesda, MD, USA; December 1–3, 2010 Guest Editors: Arifa Khan (Bethesda, MD), Patricia Hughes (Bethesda, MD) and Michael Wiebe (San Francisco, CA) Chlorine dioxide fumigation was successfully used to decontaminate a virally contaminated biotech manufacturing facility. Addressing safety, product quality, and corrosion risks were important factors in planning the building fumigation. Studies were performed to define the conditions in which minute mouse virus (MMV) is inactivated by chlorine dioxide and to understand equipment and facility risks. Written plans and procedures documented activities necessary to safely fumigate the building and requalify it to manufacture commercial product.