TY - JOUR T1 - An Improved Method for Visualizing the Morphology of Lyophilized Product Cakes JF - PDA Journal of Pharmaceutical Science and Technology JO - PDA J Pharm Sci Technol SP - 425 LP - 430 DO - 10.5731/pdajpst.2011.00749 VL - 65 IS - 4 AU - Philippe Lam AU - Thomas W. Patapoff Y1 - 2011/07/01 UR - http://journal.pda.org/content/65/4/425.abstract N2 - Due to low optical contrast, the morphology of lyophilized product cakes is difficult to observe and photograph. Furthermore, internal structures are normally not visible unless the cake is fractured. Because most lyophilized substances are hygroscopic and quite fragile, the product cake, once removed from the vial, will rapidly degrade. We propose herein a technique that allows a lyophilized product cake to be preserved, manipulated, and easily observed outside the vial. This technique yields high-quality, cross sectional images that reveal intricate fine structures without the use of expensive specialized equipment. ER -