PT  - JOURNAL ARTICLE
AU  - Sunny R. Shah
AU  - Rajesh H. Parikh
AU  - Jayant R. Chavda
AU  - Navin R. Sheth
TI  - Self-Nanoemulsifying Drug Delivery System of Glimepiride: Design, Development, and Optimization
AID  - 10.5731/pdajpst.2013.00914
DP  - 2013 May 01
TA  - PDA Journal of Pharmaceutical Science and Technology
PG  - 201--213
VI  - 67
IP  - 3
4099  - http://journal.pda.org/content/67/3/201.short
4100  - http://journal.pda.org/content/67/3/201.full
SO  - PDA J Pharm Sci Technol2013 May 01; 67
AB  - The objective of the present investigation was to develop and characterize the self-nanoemulsifying drug delivery system (SNEDDS) of glimepiride, a poorly soluble drug. Solubility of glimepiride in various vehicles was determined, and ternary phase diagrams were constructed using a suitable oil, surfactant, and cosurfactant system to find out the efficient self-emulsification system. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. Formulation optimization was carried out to optimize the droplet diameter and percent drug dissolved at 5 min. The batch prepared according to the optimized formulation showed a close agreement between observed and predicted values. Box-Behnken statistical design allowed us to understand the effect of formulation variables on the rapid dissolution of drug from SNEDDS and to optimize the formulation to obtain a rapid drug dissolution at 5 min. LAY ABSTRACT: A self-nanoemulsifying drug delivery system of glimepiride has been design, developed, and optimized. A three factor, three level Box-Behnken statistical design was employed to explore the main and interaction effect of independent variables, namely X1 (amount of Capmul MCM), X2 (amount of Acrysol K 140), and X3 (amount of Transcutol P). Percent transmittance value (Y1), droplet diameter (Y2), and percent drug released at 5 min (Y3) were the dependent variables. The Capmul MCM–Akcrysol K 140–Transcutol system was found to be the suitable ternary system that was able to release almost 80% of drug within the first 5 min. The improved dissolution of glimepiride might improve patient compliance.